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JWH-018, also known as 1-pentyl-3-(1-naphthoyl) indole, is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors CB₁ and CB₂. It was first synthesized in 1995 by Dr. John W. Huffman and his research team at Clemson University.

Synthetic cannabinoids are man-made chemicals that mimic the effects of THC, the main psychoactive compound found in marijuana. JWH-018 is considered one of the first and most widely used synthetic cannabinoids.

Effects of JWH-018

JWH-018 is known for producing effects similar to those of THC, including euphoria, relaxation, altered perception of time and space, increased appetite, and changes in mood. However, its effects can be much stronger and longer lasting compared to natural cannabis.

The potency of JWH-018 can also vary greatly depending on the dosage and method of consumption. It is typically sold as a powder or liquid, which can be smoked, vaporized, or ingested orally.

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